Studies have shown that people with natural red hair—often referred to as “gingers”—may experience pain differently due to genetic variations. This difference is primarily linked to a mutation in the MC1R gene, which is responsible for red hair and fair skin. Research suggests that redheads may have a higher sensitivity to certain types of pain, such as thermal pain from heat or cold. Interestingly, they may also require higher doses of local anesthetics (like those used at the dentist) but show increased tolerance to some other types of pain, such
as electric shock or spicy foods.
These differences in pain perception are thought to be related to how the MC1R gene affects the body’s production of melanocortins, which influence pain receptors and hormone regulation. While the science is still evolving, the findings have important implications for medical and dental care, as pain management strategies may need to be adjusted for red-haired individuals. Understanding this genetic trait helps promote more personalized and effective treatment plans—highlighting that pain tolerance can be influenced not just by experience or mindset, but also by biology.
