Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily
affecting the spine and sacroiliac joints, leading to pain and stiffness. Over
time, it can cause the vertebrae in the spine to fuse, resulting in reduced
flexibility and a hunched posture. While AS most commonly affects the
lower back, it can also impact other joints, the eyes, and, in rare cases,
organs like the heart and lungs. The exact cause of AS is unknown, but
genetic factors, particularly the HLA-B27 gene, play a significant role.
Symptoms often start in early adulthood, with men being more frequently
affected than women.
Treatment for ankylosing spondylitis focuses on managing symptoms and
preventing the progression of the disease, as there is no cure. Nonsteroidal
anti-inflammatory drugs (NSAIDs) are often the first line of treatment to
reduce pain and inflammation. Physical therapy and regular exercise are
crucial to maintaining posture and flexibility. Surgery is rarely needed but
may be considered if there is severe joint damage or spinal deformity.
Lifestyle changes, such as quitting smoking and maintaining a healthy
weight, can also help manage the condition.