Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints, which connect the lower spine to the pelvis. Over time, inflammation can lead to pain, stiffness, and in severe cases, the fusion of vertebrae, reducing spinal flexibility. While it most commonly begins in early adulthood, symptoms can appear at any age, often starting with persistent lower back pain that improves with activity but not with rest. AS can also affect other joints and organs, including the hips, shoulders, eyes, and even the heart or lungs in some cases.
The exact cause of ankylosing spondylitis is not fully understood, but genetics play a significant role, with a strong association to the HLAB27 gene. The disease tends to progress gradually, and while the severity varies between individuals, early diagnosis is crucial to managing symptoms and maintaining mobility. People with AS may notice alternating hip or back pain, morning stiffness, or fatigue, and in some cases, spinal deformities can develop over time. Although there is no cure, awareness and monitoring are important to support overall
health and daily function.
